Chemical screens for particle-induced macrophage death identifies kinase inhibitors of phagocytosis as targets for toxicity
Our chemical compendium and workflow can be expanded across cell types and assays to characterize the toxicity mechanism of newly engineered nanoparticles. The data in their current form can also be analyzed to help design future high-throughput screening for nanoparticle toxicity.
Authors
- Toshimori Kitami (ORCID: https://orcid.org/0000-0001-8418-5230)
- Uyen Tran (ORCID: https://orcid.org/0000-0002-6498-9765)
Institutions
- Texas Tech University (US)
- RIKEN Center for Integrative Medical Sciences (JP)
- Texas Tech University Health Sciences Center (US)
Publication Details
- Journal
- Journal of Nanobiotechnology
- Published
- 2024-10-13
- DOI
- https://doi.org/10.1186/s12951-024-02885-8
- Citations
- 1
- Primary Topic
- Phagocytosis and Immune Regulation
- Type
- article
- Field-Weighted Citation Impact
- 0.24
Funders
- Takeda Science Foundation
- Japan Society for the Promotion of Science