PTGER4 signaling regulates class IIa HDAC function and SPINK4 mRNA levels in rectal epithelial cells
These findings suggest a mechanism during mucosal injury whereby MSC production of PGE2 increases HDAC4, 5, and 7 activities in epithelial cells by upregulating PTGER4 signaling, ultimately increasing SPINK4 mRNA levels and extracellular release of SPINK4.
Authors
- Subra Kugathasan (ORCID: https://orcid.org/0000-0002-8686-4189)
- Sushma Chowdary Maddipatla
- Vasantha L. Kolachala (ORCID: https://orcid.org/0009-0005-6919-3765)
- Murugadas Anbazhagan (ORCID: https://orcid.org/0000-0002-2794-981X)
- Anne Wescott Dodd (ORCID: https://orcid.org/0000-0002-4009-5986)
- Garima Sharma (ORCID: https://orcid.org/0000-0002-8893-390X)
- David J. Cutler
- Amanda Randunne
- Shanta Murthy
- Jason D. Matthews
Institutions
- Emory University (US)
- Children's Healthcare of Atlanta (US)
Publication Details
- Journal
- Cell Communication and Signaling
- Published
- 2024-10-13
- DOI
- https://doi.org/10.1186/s12964-024-01879-1
- Citations
- 4
- Primary Topic
- Colorectal Cancer Surgical Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.13
Funders
- Emory University
- Crohn's and Colitis Foundation
- National Institutes of Health