Drug-resistance characteristics, genetic diversity, and transmission dynamics of multidrug-resistant or rifampicin-resistant Mycobacterium tuberculosis from 2019 to 2021 in Sichuan, China
Transmission plays a significant role in the MDR/RR-TB burden in Sichuan province, and lineage 2 strains and strains harboring KatG S315T have a high probability of transmission. Further, high levels of FQ and PZA drug resistance suggest an urgent need for drug susceptibility testing prior to designing therapeutic regimens. New anti-TB drugs need to be used standardly and TB strains should be regularly monitored for resistance to these drugs.
Authors
- Jinge He (ORCID: https://orcid.org/0000-0003-2244-9557)
- Hui Lei (ORCID: https://orcid.org/0000-0003-0937-3420)
- Jing Li (ORCID: https://orcid.org/0000-0001-9194-0695)
- Ting Li (ORCID: https://orcid.org/0000-0002-3550-7034)
- Shu Zhang (ORCID: https://orcid.org/0000-0001-6123-5418)
- Weina Wang (ORCID: https://orcid.org/0000-0003-2340-1977)
- Yuan Gao (ORCID: https://orcid.org/0000-0003-2596-4773)
- Lu He
- Wenfeng Gao
Institutions
- Sichuan Center for Disease Control and Prevention (CN)
Publication Details
- Journal
- Antimicrobial Resistance and Infection Control
- Published
- 2024-10-13
- DOI
- https://doi.org/10.1186/s13756-024-01482-6
- Citations
- 12
- Primary Topic
- Tuberculosis Research and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 4.67
Funders
- National Natural Science Foundation of China