Radiotherapy enhances the anti-tumor effect of CAR-NK cells for hepatocellular carcinoma
Our results indicate the evidence that irradiation could efficiently enhance the anti-tumor effect of CAR-NK cells in solid tumor model. The combination with radiotherapy would be an attractive strategy to improve therapeutic efficacy of CAR-NK cells for solid tumors.
Authors
- Kunyuan Wang
- Zhaoze Guo (ORCID: https://orcid.org/0000-0001-8847-7740)
- Yuetong Guo (ORCID: https://orcid.org/0009-0007-8744-2547)
- Zishen Liu
- Hongjin Xiang
- Qiankun Xie (ORCID: https://orcid.org/0000-0002-2635-7193)
- Ryohichi Sugimura (ORCID: https://orcid.org/0000-0001-5701-3628)
- Guozhu Xie (ORCID: https://orcid.org/0000-0002-3377-3099)
- Ying Chen (ORCID: https://orcid.org/0009-0005-8351-6620)
- Fei Wang (ORCID: https://orcid.org/0000-0003-0885-8178)
- Xin Dong
- Yuqin Zhang (ORCID: https://orcid.org/0000-0001-5629-0770)
- Yao Sun (ORCID: https://orcid.org/0000-0001-7735-653X)
- Ling Jing (ORCID: https://orcid.org/0000-0002-4919-8121)
- Xiaotong Lin
- Han Zhang (ORCID: https://orcid.org/0009-0000-8542-2509)
Institutions
- Key Laboratory of Guangdong Province (CN)
- Nanfang Hospital (CN)
- Southern Medical University (CN)
- University of Hong Kong (HK)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2024-10-13
- DOI
- https://doi.org/10.1186/s12967-024-05724-4
- Citations
- 25
- Primary Topic
- Immune Cell Function and Interaction
- Type
- article
- Field-Weighted Citation Impact
- 6.01
Funders
- National Natural Science Foundation of China
- Southern Medical University
- Nanfang Hospital
- Guangzhou Municipal Science and Technology Project
- Basic and Applied Basic Research Foundation of Guangdong Province