Dynamics of the effect of local treatment on the frequency of nuclei with perinuclear vacuole in the cytogram of buccal epithelium in patients with the erosive and ulcerative form of the lichen planus in the oral cavity mucosa lining

INTRODUCTION . The use of cytologic studies allows evaluating the dynamics of the local treatment conducted of the EUF (L43.82) LP OCML (Erosive and Ulcerative Form of the Lichen Planus in the Oral Cavity Mucosa Lining) in a comprehensive way. AIM . Evaluation of the effect of local the effect of local treatment on the frequency of nuclei with perinuclear vacuole in the cytogram of buccal epithelium of the reticular mesh surface, hyperemic zone and erosive and ulcerative elements in patients with the erosive and ulcerative form of the flat lichen of the oral mucosa (L43.82). MATERIAL AND METHODS . 86 patients with the EUF (L43.82) LP OCML participated in the study. The number of nuclei with perinuclear vacuole was assessed in cytologic preparations obtained from buccal epithelium, which was a reliable criterion to confirm the nature of chronic inflammation. The dynamics of cells with necrosis in the cytogram of buccal epithelium was evaluated using nonparametric criteria as follows: Mann-Whitney test (comparison between subgroups and with the experimental group), Wilcoxon test (to compare within subgroups before and after treatment). Significant differences did not exceed 0.05. RESULTS . In the course of the treatment conducted in the cytogram of buccal epithelium there was a decrease in the frequency of nuclei with perinuclear vacuole of the reticular mesh surface and erosive and ulcerative elements in patients of the main clinical groups 1 and 2(p< 0.001). When analyzing the frequency of nuclei with perinuclear vacuole in the cytogram of buccal epithelium taken from the surface of erosions and ulcers, there were significant differences before and after treatment according to the Wilcoxon test. In the clinical group using the treatment method according to federal guidelines, the frequency of nuclei with perinuclear vacuole was observed at a significance level of p< 0.05, and when using the local treatment complex proposed respectively at p< 0.001. CONCLUSION . Thus, in the cytogram of buccal epithelium according to the Wilcoxon test before and after the local treatment proposed, there was a more evident decrease in the number of nuclei with perinuclear vacuole than with the use of federal guidelines.