Mind Games: A Curious Case of Primary CNS Lymphoma Masquerading as Glioblastoma Multiforme

The rare diffuse B-cell lymphoma subtype of primary central nervous system lymphomas (PCNSL) typically presents with nonspecific symptoms. Many of these symptoms overlap with those reported in cases of glioblastoma multiforme (GBM). However, despite the overlap in symptomatology, the two CNS tumors exhibit distinctly different imaging findings on MRI, which aids in diagnosis. Here, we present a rare case of the diffuse B-cell lymphoma subtype of PCNSL in the anterior right frontal lobe, initially diagnosed as GBM due to specific imaging findings. The diagnosis was corrected to PCNSL following biopsy and resection.