Sensitizing cholangiocarcinoma to chemotherapy by inhibition of the drug-export pump MRP3
Genetic and pharmacological MRP3 inhibition enhances the anti-CCA effect of several drugs, which constitutes a promising strategy to improve the response to chemotherapy in CCA patients.
Authors
- José J.G. Marı́n (ORCID: https://orcid.org/0000-0003-1186-6849)
- Matías A. Ávila (ORCID: https://orcid.org/0000-0001-6570-3557)
- Ricardo Espinosa-Escudero (ORCID: https://orcid.org/0000-0002-4811-8230)
- Thomas Efferth (ORCID: https://orcid.org/0000-0002-2637-1681)
- Ana Peleteiro‐Vigil (ORCID: https://orcid.org/0000-0002-5990-5037)
- Elisa Herráez (ORCID: https://orcid.org/0000-0001-9271-3320)
- Helen Hammer (ORCID: https://orcid.org/0000-0001-8187-0240)
- Óscar Briz (ORCID: https://orcid.org/0000-0001-6891-1554)
- Elisa Lozano (ORCID: https://orcid.org/0000-0002-7714-1691)
- Rocı́o I.R. Macı́as (ORCID: https://orcid.org/0000-0002-4748-0326)
- Maitane Asensio (ORCID: https://orcid.org/0000-0002-8723-6053)
- Onat Kadioglu
- Maria Luz Martínez‐Chantar (ORCID: https://orcid.org/0000-0002-6446-9911)
- Laura Perez‐Silva (ORCID: https://orcid.org/0000-0002-6730-2746)
- Jesús M. Bañales (ORCID: https://orcid.org/0000-0002-5224-2373)
- Diego Bueno-Sacristán
- Oliver Pötz
Institutions
- Universidad de Salamanca (ES)
- Johannes Gutenberg University Mainz (DE)
- Natural and Medical Sciences Institute (DE)
- Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (ES)
- Instituto de Investigación Biomédica de Salamanca (ES)
- Signatope GmbH (Germany)
Publication Details
- Journal
- Biomedicine & Pharmacotherapy
- Published
- 2024-10-13
- DOI
- https://doi.org/10.1016/j.biopha.2024.117533
- Citations
- 3
- Primary Topic
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Type
- article
- Field-Weighted Citation Impact
- 1.72