N-butanol extract of Broussonetia papyrifera (L.) L′Hér. ex Vent root bark alleviates atopic dermatitis by targeting E3 ubiquitin ligase WWP1 to promote NLRP3 degradation
The NE-BPRB and its primary bioactive constituent, CA, effectively inhibit the formation of the NLRP3 inflammasome and impede cell pyroptosis by promoting K48-linked ubiquitin-dependent proteasomal degradation of NLRP3 through binding to the E3 ubiquitin ligase WWP1, thereby resulting in improved AD.
Authors
- Luyong Zhang (ORCID: https://orcid.org/0000-0003-1164-7371)
- Zhiming Ye (ORCID: https://orcid.org/0009-0009-9389-8182)
- Liangkun Weng
- Cheng Zeng (ORCID: https://orcid.org/0000-0003-2342-6963)
- Bing Liu (ORCID: https://orcid.org/0000-0002-6086-253X)
- Can Yu
- Song Yuanming
- Yihang Huang (ORCID: https://orcid.org/0009-0007-2699-5834)
- Wenjing Xiang
- Yuxuan Song
- Huiwen Yang (ORCID: https://orcid.org/0009-0003-5768-8424)
- Zixuan Lai
Institutions
- Guangdong Pharmaceutical University (CN)
- First Affiliated Hospital of Guangdong Pharmaceutical University (CN)
Publication Details
- Journal
- Biomedicine & Pharmacotherapy
- Published
- 2024-10-13
- DOI
- https://doi.org/10.1016/j.biopha.2024.117561
- Citations
- 4
- Primary Topic
- Dermatology and Skin Diseases
- Type
- article
- Field-Weighted Citation Impact
- 2.14