GR113808, a serotonin receptor 4 antagonist, prevents high-fat-diet-induced obesity, fatty liver formation, and insulin resistance in C57BL/6J mice
In summary, GR113808 protected against fatty liver formation and improved inflammation in the liver and adipose tissue. Downregulation of HTR4 ameliorated insulin resistance in the liver. These results suggest that HTR4 could serve as a promising therapeutic target for metabolic diseases.
Authors
- Woo‐Jae Park (ORCID: https://orcid.org/0000-0002-5770-7096)
- Kyoung Kon Kim (ORCID: https://orcid.org/0000-0003-0374-2571)
- Dae Ho Lee (ORCID: https://orcid.org/0000-0002-8832-3052)
- Min Hee Kim (ORCID: https://orcid.org/0000-0002-3487-7746)
- Su‐Jeong Kim (ORCID: https://orcid.org/0000-0002-4435-5757)
Institutions
- Gachon University (KR)
- Ewha Womans University (KR)
- Gachon University Gil Medical Center (KR)
- Chung-Ang University (KR)
Publication Details
- Journal
- BMC Pharmacology and Toxicology
- Published
- 2024-10-11
- DOI
- https://doi.org/10.1186/s40360-024-00800-3
- Citations
- 2
- Primary Topic
- Adipose Tissue and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.65
Funders
- National Research Foundation
- Korea Health Industry Development Institute
- National Research Foundation of Korea
- Ministry of Education, Science and Technology