Titanium exposure and gestational diabetes mellitus: associations and potential mediation by perturbation of amino acids in early pregnancy
In this prospective study, we uniquely identified a correlation between early pregnancy titanium exposure and increased GDM risk. We unveiled novel insights into how perturbations in amino acid metabolism may mediate the link between titanium exposure and GDM. Notably, choline, creatine, and L-alanine emerged as key mediators influencing this association. Our findings imply that elevated titanium exposure in early pregnancy can lead to amino acid dysmetabolism, thereby elevating GDM risk.
Authors
- Hongxia Ma (ORCID: https://orcid.org/0000-0002-9821-6955)
- Tian‐Yu Sun (ORCID: https://orcid.org/0000-0002-7746-479X)
- Yuanyan Dou
- Xin Xu (ORCID: https://orcid.org/0000-0002-2469-6933)
- Jiangbo Du (ORCID: https://orcid.org/0000-0002-5717-9385)
- Yuting Peng (ORCID: https://orcid.org/0000-0003-2360-5638)
- Zhibin Hu (ORCID: https://orcid.org/0000-0002-8277-5234)
- Zhonghua Shi (ORCID: https://orcid.org/0000-0001-8728-9158)
- Cong Liu (ORCID: https://orcid.org/0000-0001-6024-3037)
- Xiaoyan Wang (ORCID: https://orcid.org/0000-0002-5920-8709)
- Yuan Lin (ORCID: https://orcid.org/0000-0003-3091-9889)
- Bo Xu (ORCID: https://orcid.org/0000-0002-1165-7302)
- Hong Lv
- Yue Jiang (ORCID: https://orcid.org/0000-0002-9427-6627)
- Shuxin Xiao
- Xiumei Han (ORCID: https://orcid.org/0009-0003-6244-4838)
- Qi Xi (ORCID: https://orcid.org/0000-0001-6993-3819)
- Yangqian Jiang (ORCID: https://orcid.org/0000-0003-1629-6777)
Institutions
- Nanjing Maternity and Child Health Care Hospital (CN)
- Suzhou Municipal Hospital (CN)
- Changzhou No.2 People's Hospital (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- Environmental Health
- Published
- 2024-10-12
- DOI
- https://doi.org/10.1186/s12940-024-01128-5
- Citations
- 2
- Primary Topic
- Birth, Development, and Health
- Type
- article
- Field-Weighted Citation Impact
- 2.22
Funders
- National Natural Science Foundation of China