FTO/m6A mediates miR-138-5p maturation and regulates gefitinib resistance of lung adenocarcinoma cells by miR-138-5p/LCN2 axis
FTO suppressed the processing of miR-138-5p and then modulated the proliferation, death, and ferroptosis of gefitinib-resistant cells through the miR-138-5p/LCN2 pathway, which may put forward novel insights for clinically ameliorating the therapeutic effect of gefitinib in LUAD.
Authors
- Dongxiao Ding (ORCID: https://orcid.org/0000-0002-3347-0821)
- Ke Shi (ORCID: https://orcid.org/0000-0001-6776-2710)
- Junjie Ying (ORCID: https://orcid.org/0000-0002-0482-6796)
- Chong Zhang (ORCID: https://orcid.org/0000-0001-9609-8855)
- Wenjun Shang (ORCID: https://orcid.org/0000-0002-9234-979X)
- Li Wang
- Zhongjie Chen (ORCID: https://orcid.org/0009-0000-6844-0449)
Institutions
- Zhejiang University (CN)
Publication Details
- Journal
- BMC Cancer
- Published
- 2024-10-12
- DOI
- https://doi.org/10.1186/s12885-024-13036-5
- Citations
- 11
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 2.57
Funders
- Medical and Health Research Project of Zhejiang Province