SCYL1-mediated regulation of the mTORC1 signaling pathway inhibits autophagy and promotes gastric cancer metastasis
SCYL1 is a significant contributor to GC progression, promoting metastasis by activating the mTORC1 signaling pathway and inhibiting autophagy. These findings suggest SCYL1 as a potential therapeutic target for GC treatment.
Authors
- Xian Gao (ORCID: https://orcid.org/0000-0001-7937-5478)
- Jinlong Liu (ORCID: https://orcid.org/0000-0001-6248-9663)
- Zhiqi Chen (ORCID: https://orcid.org/0009-0001-9111-0197)
- Junjie Chen (ORCID: https://orcid.org/0000-0002-1493-2189)
- Wanjiang Xue (ORCID: https://orcid.org/0000-0002-0137-7331)
- Zihao Zhao (ORCID: https://orcid.org/0000-0002-9470-0010)
- Yilin Hu (ORCID: https://orcid.org/0009-0005-5586-9189)
- Weijie Zang
Institutions
- Nantong University (CN)
- Affiliated Hospital of Nantong University (CN)
Publication Details
- Journal
- Journal of Cancer Research and Clinical Oncology
- Published
- 2024-10-12
- DOI
- https://doi.org/10.1007/s00432-024-05938-5
- Citations
- 1
- Primary Topic
- Autophagy in Disease and Therapy
- Type
- article
- Field-Weighted Citation Impact
- 0.39
Funders
- Natural Science Foundation of Nantong City
- National Natural Science Foundation of China