Effects of BRCA1 overexpression via the NRF2 / HO1 / NQO1 pathway on oral cancer cells proliferation, migration, and apoptosis
Experiments involving oral cancer cells confirmed that <i>BRCA1</i> overexpression could up-regulate the NRF2 signalling pathway, reduce oxidative damage, and inhibit cell proliferation and other biological behaviours. The BRCA1 and NRF2 pathways might be associated with oral cancer occurrence and development.
Authors
- Zhengyi Shan
- Xiaofei Yu (ORCID: https://orcid.org/0009-0005-2892-9238)
- Jing Deng (ORCID: https://orcid.org/0000-0002-1736-1801)
- Hui Zhang (ORCID: https://orcid.org/0000-0001-9191-1261)
- Yao Liu (ORCID: https://orcid.org/0000-0002-7310-8800)
- Zheng Sun (ORCID: https://orcid.org/0000-0001-7427-087X)
- Chunyan Wan (ORCID: https://orcid.org/0009-0001-0417-8506)
- Junjie Tong (ORCID: https://orcid.org/0009-0009-5715-8961)
- Pei Sun
Institutions
- Qingdao University (CN)
- Beijing Tian Tan Hospital (CN)
- Affiliated Hospital of Qingdao University (CN)
Publication Details
- Journal
- Heliyon
- Published
- 2024-10-01
- DOI
- https://doi.org/10.1016/j.heliyon.2024.e38977
- Citations
- 3
- Primary Topic
- Genomics, phytochemicals, and oxidative stress
- Type
- article
- Field-Weighted Citation Impact
- 0.70
Funders
- Qingdao University