I Dentification Immunohistological Changes in the Thymus Gland of Male and Female Rats With Indocrine Glands Disorder

Endocrine disorders is the result of a hormone imbalance, a condition characterized by a gland producing too much or too little of a hormone. This imbalance can be caused by:Issues with the endocrines feedback system−its main job is to keep hormones in the body perfectly balanced but it can malfunction and cause an imbalance a genetic disorder or infection or disease or injury to an an endocrine gland.The study amied to know the changes that occur in the thymus gland as a result of endocrine disorders in order to explain and analyze them accurately,as well as an immunological comparison between males and females.Twenty−four male and female rats Rattus norvegicus were divided into three groups of eight rats each : The first group (G1) received normal saline for 21 dayꓼ The second group male(G2), rats were given 6 mg / kg metoclopramide by intraperitoneal injection for hyperprolactinemia induction for 21 daysꓼ The third group femals (G3)was given metoclopramide 6 mg / kg intraperitoneally to induce hyperprolactinemic rats.After the end of experimental [21 days ], Measure prolactin hormone, and the thymus gland was removed, processed and examine for histomorphological changes. The result of the study revealed that is a significant (p<0.05) in prolactin and( WBC) in the two hyperprolactinemia group when compared with the control group.And when compared a group of hyperprolactinemia the males and agroup hyperprolactin females.Note a significant difference(increase)in the male group compared to the female group.And the resuit of the study showed asignificant decrease(p<0.05) in weight and size the thymus gland in hyperprolactinemia male and female group compared with the control group.The histologicale study in male and female laboratory rats of the two hyperprolactinemia group also showed clear histological changes compared to the negative control group,reprsented the cortex area increased compared with the medulla area ,where the cortex−to−medulla ratio was about 3:1 .The limited numbers of epithelial cells were observed in the medulla area where the increase in lymphocyte numbers was significantly observed.Also, Hassall‘s corpuscles were not observed in the medulla.AS note the limited deposition or almost absence of collagen fibre in the medulla area.The study concluded endocrine disruption has a significant and noticeable effect on the size and weight of the thymus gland on the one hand and a histological effect on the other hand.