Bibliometric analysis of chimeric antigen receptor macrophage therapy

Chimeric antigen receptor macrophage (CAR-M) therapy refers to the implantation of specific edited CAR genes into macrophages to equip macrophages to bind to the surface of tumor cells through specific antigens and subsequently activate the activity of macrophages to achieve tumor-killing function. This bibliometric analysis aims to decipher the emerging trends in CAR-M therapy and provide insights for future research. In this review, all relevant literature on CAR-M therapy in the Web of Science has been analyzed for its research trends in this field by using VOS viewer, Pajek, Microsoft Excel, and Endnote software. According to the research findings, it is the most productive in the United States. The institution with the highest number of publications is the University of Pennsylvania. Frontiers in Immunology is one of the most productive journals. Kenderian Saad Sirop publishes the largest number of articles. Keyword cluster analysis shows that the current research trend is more focused on tumor-associated macrophages as well as immunotherapy, exploring the mechanisms and modalities of CAR-M therapy. This study provides a comprehensive summary and analysis of global research trends in CAR-M therapy. In the past few decades, the number of high-quality papers in this field has increased significantly, and CAR-M therapy has provided hope for tumor treatment, truly bringing health gospel to the majority of tumor patients, patients with major diseases, and sub-healthy people.