Head‐to‐head comparison of leading blood tests for Alzheimer's disease pathology
Plasma p-tau217 measures most accurately classified amyloid and tau status. Plasma Aβ42/Aβ40 had relatively low accuracy in classification of amyloid status. Plasma p-tau217 measures had higher correlations with cortical thickness than NfL. Correlations of plasma biomarkers with dementia symptoms were relatively low.
Authors
- Benjamin Saef
- Michael V. Baratta (ORCID: https://orcid.org/0000-0001-7273-1994)
- Duygu Tosun (ORCID: https://orcid.org/0000-0001-8644-7724)
- Nicholas James Ashton (ORCID: https://orcid.org/0000-0002-3579-8804)
- Anthony W. Bannon
- David Raunig (ORCID: https://orcid.org/0000-0003-4549-1280)
- Kyle Ferber (ORCID: https://orcid.org/0000-0002-4730-6993)
- Janaky Coomaraswamy
- Yulia Mordashova
- Jeffrey L. Dage (ORCID: https://orcid.org/0000-0002-2192-1699)
- Erin G. Rosenbaugh (ORCID: https://orcid.org/0000-0002-3909-9760)
- Carrie E. Rubel (ORCID: https://orcid.org/0000-0003-1371-2536)
- Gallen Triana‐Baltzer (ORCID: https://orcid.org/0000-0003-0612-1236)
- Kellen K. Petersen (ORCID: https://orcid.org/0000-0003-3195-3456)
- Emily A. Meyers (ORCID: https://orcid.org/0000-0002-0886-6218)
- Suzanne E. Schindler (ORCID: https://orcid.org/0000-0002-1680-1465)
- Henrik Zetterberg (ORCID: https://orcid.org/0000-0003-3930-4354)
- Yan Li (ORCID: https://orcid.org/0000-0002-6857-9464)
- Leslie M. Shaw (ORCID: https://orcid.org/0000-0002-7650-1210)
- William Z. Potter
- Ziad S. Saad
- Lei Du‐Cuny
Institutions
- Alzheimer's Association (US)
- Biogen (United States) (US)
- Johnson & Johnson (United States) (US)
- University of Wisconsin–Madison (US)
- University of California, San Francisco (US)
- Washington University in St. Louis (US)
- Foundation for the National Institutes of Health (US)
- Sahlgrenska University Hospital (SE)
- University of California System (US)
- AbbVie (United States) (US)
- UK Dementia Research Institute (GB)
- AbbVie (Germany) (DE)
- Takeda (United States) (US)
- Banner Sun Health Research Institute (US)
- National Hospital for Neurology and Neurosurgery (GB)
- Banner Alzheimer’s Institute
- Indiana University School of Medicine
- University College London (GB)
- Indiana University – Purdue University Indianapolis (US)
- University of Pennsylvania (US)
- University of Gothenburg (SE)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-10-12
- DOI
- https://doi.org/10.1002/alz.14315
- Citations
- 123
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 47.43
Funders
- Foundation for the National Institutes of Health
- Alzheimer's Association
- Alzheimer's Drug Discovery Foundation
- Biogen
- AbbVie
- Takeda Pharmaceutical Company
- National Institutes of Health
- National Institute on Aging
- Janssen Research and Development