Prenatal Development of Rabbit Cerebellum

The present study's purpose was to give an overview of the rabbit cerebellum's prenatal developmental stages. Forty embryos of prenatal ages (E10, E15, E17, E20, E25, E25 and E30) were obtained from the rabbit. The cerebellum primordium appeared on day 10 (E10). At E25 the cerebellar primordium formed from the neuroepithelium, mantle layer and marginal layer. The peripheral layer of neuroepithelium transformed to external granular layer (EGL). This EGL is termed as second germinal layer. The EGL molecular development was a distinct structure in the developing cerebellum that afterward disappeared. On day 30 prenatal embryos of rabbits, the cerebellum was not fully differentiated. The cerebellar cortex consisted of external granular and internal granular layers. An extended process that takes place during prenatal and postnatal life gives the mature cerebellum its ultimate structure. In the current study, the rabbit cerebellum's prenatal development and age-related histogenesis were connected.