Serum Interleukin 18 and NLRP3 in patients with Alopecia Areata

Background: Alopecia areata (AA) is a persistent hair follicle inflammatory condition with T lymphocyte invasion. Interleukin-18 (IL-18) and inflammatory proteins such as NOD-like receptor family pyrin domain containing 3 (NLRP3) have been connected with several inflammatory and autoimmune skin conditions. Objectives: To evaluate serum IL-18 and NLRP3 in patients with AA. Materials and methods: This case-control study comprised 50 patients with AA and 50 normal, healthy persons of comparable age and sex as a control group. Severity of AA was evaluated using the SALT score. ELISA kits were used to determine serum IL-18 and NLRP3 levels.Results: Serum IL-18 and NLRP3 levels were considerably greater in patients vs. controls (P= 0.01,