The effect of topical hyaluronic acid compared to low level laser therapy in treatment of oral lichen planus patients.

Objectives: To evaluate clinically the effectiveness of topical hyaluronic acid compared to low level laser therapy in treatment of oral lichen planus patients.Material and Methods: Forty two Patients with clinical and histological diagnosis of EOLP were included in randomized clinical trials. They were divided into two groups: Group A: 21 Patients was treated with HA (0.2%) for local application directly on the affected area. Group B: 21 patients treated by Low level laser therapy performed by using a semiconductor diode laser 635 nm. Application of 635 nm wavelength will transmitted to the lesion via an optical fiber equipped with a diffuser tip. The laser power from the end of the optical fiber did not exceed 300 mW. Each session will be 10 min. Results: Both groups showed a statistically significant difference from baseline to follow -up periods. Where both groups showed a remarkable reduction in pain and size of lesions. Conclusion: Topical application of hyaluronic acid was effective and can be considered as an alternative therapy for low level laser therapy in the treatment of erosive-atrophic OLP.