Low serum DEL-1 and high serum sP-sel levels in overweight and obese Subjects and their relation to platelet count

Obesity characterized by an elevated platelet count and hyper activation causing a pro-thrombotic state. Soluble P-selectin (sP-sel), an obesity-associated protein that enhences platelet activation, facilitates and augments thrombosis. Developmental endothelial locus-1(DEL-1) is an anti-inflammatory protein that enhances inflammation clearance; it inhibits platelet-monocyte aggregation hence thrombosis inhibition. However, serum levels of DEL-1 in obese and overweight subjects and their relation to platelet count and sP-sel have not been detected to date.Methods: 22 controls (Group A), 22 overweight subjects (Group B), and 22 obese subjects (Group C) were enrolled in this case-control study. Serum levels of PLC, MPV, RBCs, HB, WBCs, Lymphocyte count, sP-sel, and DEL-1 were measured. Results: levels of HB, DEL-1, and RBCs were lowest in group (C) and highest in group (A) with a statistically significant difference between these two groups. While, PLC,MPV, WBCs, lymphocyte count, and sP-sel levels were highest in group (C) and lowest in group (A). BMI, platelets, and WBCs count correlated positively with sP-sel and negatively with DEL-1 levels. sP-sel and DEL-1 showed a negative correlation with each other.Conclusion: Increased sP-sel and decreased DEL-1 levels in overweight and obese might have a role in raising thrombosis risk and inflammation in these subjects.