Cancer-associated foam cells hamper protective T cell immunity and favor tumor progression in human colon carcinogenesis
FC exert immunosuppressive activity through a TGF-β-related pathway, resulting in a CD8-excluded microenvironment and identifying immunosuppressed tumors with worse prognosis in patients with primary CRC. FC association with patient BMI and dyslipidemia might explain the link of CRC with obesity, and offers novel therapeutic and preventive perspectives in this specific clinical setting.
Authors
- Agata Cova (ORCID: https://orcid.org/0000-0003-2117-0757)
- Barbara Vergani
- Luca Lalli (ORCID: https://orcid.org/0000-0002-4472-628X)
- Daniele Morelli (ORCID: https://orcid.org/0000-0002-1823-3764)
- Massimo Milione (ORCID: https://orcid.org/0000-0002-1202-139X)
- Martina Stroscia
- Marco Vitellaro (ORCID: https://orcid.org/0000-0001-8134-5315)
- Paola Frati (ORCID: https://orcid.org/0000-0002-1242-173X)
- Laura Cattaneo (ORCID: https://orcid.org/0000-0001-8890-719X)
- Vincenzo Lagano (ORCID: https://orcid.org/0000-0002-5965-0361)
- Flavio Arienti (ORCID: https://orcid.org/0000-0002-4919-4227)
- Biagio Eugenio Leone (ORCID: https://orcid.org/0000-0002-6978-2405)
- Manuela Gariboldi (ORCID: https://orcid.org/0000-0001-8406-165X)
- Giovanna Sabella (ORCID: https://orcid.org/0000-0002-1673-424X)
- Simonetta Guarrera (ORCID: https://orcid.org/0000-0003-4400-1817)
- Paola Antonia Corsetto (ORCID: https://orcid.org/0000-0003-3849-8548)
- Licia Rivoltini (ORCID: https://orcid.org/0000-0002-2409-6225)
- Luca Sorrentino (ORCID: https://orcid.org/0000-0002-3963-2385)
- Elena Daveri (ORCID: https://orcid.org/0000-0001-8351-2762)
- Patrizia Pasanisi (ORCID: https://orcid.org/0000-0001-6278-3491)
- Elena Casiraghi (ORCID: https://orcid.org/0000-0003-2024-7572)
- Veronica Huber (ORCID: https://orcid.org/0000-0001-6304-3575)
- Giulio Ferrero (ORCID: https://orcid.org/0000-0002-4580-0680)
- Angela Maria Rizzo (ORCID: https://orcid.org/0000-0002-8582-0432)
- Marta Zorza
Institutions
- University of Milan (IT)
- Italian institute for Genomic Medicine (IT)
- Candiolo Cancer Institute (IT)
- Fondazione IRCCS Istituto Nazionale dei Tumori (IT)
- University of Turin (IT)
- University of Milano-Bicocca (IT)
Publication Details
- Journal
- Journal for ImmunoTherapy of Cancer
- Published
- 2024-10-01
- DOI
- https://doi.org/10.1136/jitc-2024-009720
- Citations
- 12
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 3.39
Funders
- Ministero dell’Istruzione, dell’Università e della Ricerca
- Associazione Italiana per la Ricerca sul Cancro
- Fondazione Pezcoller