Sex hormones and risk of lung and colorectal cancers in women: a Mendelian randomization study
The roles of sex hormones such as estradiol, testosterone, and sex hormone-binding globulin (SHBG) in the etiology of lung and colorectal cancers in women, among the most common cancers after breast cancer, are unclear. This Mendelian randomization (MR) study evaluated such potential causal associations in women of European ancestry. We used summary statistics data from genome-wide association studies on sex hormones and from the Trøndelag Health Study (HUNT) and large consortia on cancers. There was suggestive evidence of 1-standard deviation increase in total testosterone levels being associated with a lower risk of lung non-adenocarcinoma (hazard ratio 0.60, 95% confidence interval 0.37-0.98) in the HUNT Study. However, this was not confirmed by using data from a larger consortium. In general, we did not find convincing evidence to support a causal role of sex hormones on risk of lung and colorectal cancers in women of European ancestry.
Authors
- Jewel Samadder
- Yi‐Qian Sun (ORCID: https://orcid.org/0000-0002-9634-9236)
- Demetrius Albanes (ORCID: https://orcid.org/0000-0001-8330-4293)
- Xiao‐Mei Mai (ORCID: https://orcid.org/0000-0002-0426-7496)
- Sébastien Küry (ORCID: https://orcid.org/0000-0001-5497-0465)
- Christopher I. Li (ORCID: https://orcid.org/0000-0003-1543-0743)
- Marion Denos (ORCID: https://orcid.org/0000-0003-4134-9156)
- Emily White (ORCID: https://orcid.org/0000-0002-8935-6227)
- Andrea N. Burnett‐Hartman (ORCID: https://orcid.org/0000-0003-4009-0680)
- Ben Michael Brumpton (ORCID: https://orcid.org/0000-0002-3058-1059)
- Mark A. Jenkins (ORCID: https://orcid.org/0000-0002-8964-6160)
- Yafang Li (ORCID: https://orcid.org/0000-0002-1645-1995)
- Peter T. Campbell
Institutions
- National Institutes of Health (US)
- Albert Einstein College of Medicine (US)
- Kaiser Permanente (US)
- The University of Melbourne (AU)
- Baylor College of Medicine (US)
- Norwegian University of Science and Technology (NO)
- Fred Hutch Cancer Center (US)
- St Olav's University Hospital (NO)
- Houston Institute for Clinical Research (US)
- Mayo Clinic in Arizona (US)
- National Cancer Institute (US)
- Génétique Médicale & Génomique Fonctionelle (FR)
- Nantes Université (FR)
Publication Details
- Journal
- Scientific Reports
- Published
- 2024-10-12
- DOI
- https://doi.org/10.1038/s41598-024-75305-4
- Citations
- 3
- Primary Topic
- Genetic Associations and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 1.65
Funders
- U.S. Department of Health and Human Services
- American Cancer Society
- Damon Runyon Cancer Research Foundation
- World Health Organization
- Brigham and Women's Hospital
- Florida Department of Health
- Memorial Sloan-Kettering Cancer Center
- Univerzita Karlova v Praze
- Johns Hopkins University
- University of Pittsburgh
- Harvard T.H. Chan School of Public Health
- Deutsches Krebsforschungszentrum
- University of South Florida
- Norges Teknisk-Naturvitenskapelige Universitet
- Moffitt Cancer Center
- Marshfield Clinic Research Foundation
- Mike and Josie Harper Cancer Research Institute
- Centres de Recerca de Catalunya
- Cancer Research UK
- National Institute for Health and Care Research
- Imperial College London
- Institut National de la Santé et de la Recherche Médicale
- Grantová Agentura České Republiky
- Bundesministerium für Bildung und Forschung
- Chonnam National University
- Fundación Científica Asociación Española Contra el Cáncer
- Cancerfonden
- Generalitat de Catalunya
- Ministerstvo Zdravotnictví Ceské Republiky
- Ministerio de Economía y Competitividad
- Ligue Contre le Cancer
- Vetenskapsrådet
- Helse Midt-Norge
- Umeå Universitet
- Associazione Italiana per la Ricerca sul Cancro
- Deutsche Krebshilfe
- Institut Gustave-Roussy
- Mutuelle Générale de l'Education Nationale
- Karl-Franzens-Universität Graz
- Medizinische Universität Graz
- Xunta de Galicia
- Biobanco Vasco
- Chonnam National University Hwasun Hospital
- National Institutes of Health
- Centers for Disease Control and Prevention
- Fakultet for medisin og helsevitenskap, Norges Teknisk-Naturvitenskapelige Universitet
- Canadian Institutes of Health Research
- Medical Research Council
- World Cancer Research Fund
- National Health and Medical Research Council
- Cancer Council Victoria
- Agència de Gestió d'Ajuts Universitaris i de Recerca
- Instituto de Salud Carlos III
- Wageningen University and Research
- NIHR Imperial Biomedical Research Centre
- School of Public Health, Imperial College London
- Faculty of Medicine and Health, University of Sydney
- Norwegian Institute of Public Health
- National Cancer Institute