A multilayer network analysis of Alzheimer's disease pathogenesis: Roles for p‐tau, synaptic peptides, and physical activity
Network-based approaches simultaneously model interdependent biological processes. Secretory synaptic peptides were influential contributors to the multilayer network. Older adults with lower physical activity had adverse relationships among pathology. There was interdependence among phosphorylated tau, synaptic integrity, and tangles. Network methods elucidate the role of physical activity in cognitive impairment.
Authors
- Julie A. Schneider (ORCID: https://orcid.org/0000-0003-0756-5007)
- Alfredo Ramos‐Miguel (ORCID: https://orcid.org/0000-0001-6259-1836)
- William G. Honer (ORCID: https://orcid.org/0000-0002-7628-5108)
- Andrea A. Jones (ORCID: https://orcid.org/0000-0003-0804-967X)
- David Bennett (ORCID: https://orcid.org/0000-0001-5354-152X)
- Philip L. De Jager (ORCID: https://orcid.org/0000-0002-8057-2505)
- Kristina M. Gicas (ORCID: https://orcid.org/0000-0001-7917-6727)
- Vladislav Petyuk (ORCID: https://orcid.org/0000-0003-4076-151X)
- Sue E. Leurgans (ORCID: https://orcid.org/0000-0003-2536-1665)
- Kaitlin B. Casaletto
Institutions
- University of British Columbia (CA)
- Pacific Northwest National Laboratory (US)
- University of the Fraser Valley (CA)
- University of California, San Francisco (US)
- Columbia University Irving Medical Center (US)
- BioCruces Health research Institute (ES)
- Centro de Investigación Biomédica en Red de Salud Mental (ES)
- University Memory and Aging Center (US)
- BC Mental Health & Substance Use Services (CA)
- Rush University (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-10-12
- DOI
- https://doi.org/10.1002/alz.14286
- Citations
- 5
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.63
Funders
- Ministerio de Ciencia, Innovación y Universidades
- Eusko Jaurlaritza
- National Institutes of Health
- Canadian Institutes of Health Research
- Berrikuntza + Ikerketa + Osasuna Eusko Fundazioa
- National Institute on Aging