What is the impact of histone modification-based treatment in cardiovascular diseases in modern medicine?

Cardiovascular diseases (CVDs) are a serious group of diseases worldwide1. Currently, there are a vast number of treatments, including coronary bypass surgery, beta-blockers, diuretics, vitamin C and ACE inhibitors. However, they appear to have unique side effects despite significant therapeutic effects, such as hypokalaemia and cogitative disorders in some patients, especially those with other conditions2. Under these circumstances, effective and targeted drugs against CVDs are in high need of development. Histone modification, as a novel and rapidly developing field, has already attracted many researchers to investigate its role in CVD outbreaks and potential therapeutic effects against CVDs. However, there are currently no certified histone modification-based drugs in CVD therapies. This dissertation will focus on histone modification mechanisms, comparison with traditional CVD drugs, clinical prospects and potential investigation directions as well as current limitations.