Resistance and resilience to tau pathology in Alzheimer's disease: Effects of age, sex, and <i>APOE</i> alleles
We investigated cognitive resistance and resilience to tau pathology in Alzheimer's disease (AD).This study included individuals who were not diagnosed with AD.Braak stages 0-II and III-VI were considered as a measure of resistance and resilience, respectively.Resistance was stronger at ages younger than 85 years in non-carriers of the apolipoprotein E (<i>APOE</i>) ε4 allele.Resilience increased with age for each <i>APOE</i> allele independently of sex.At age 85 years and older, high resilience (>50%) was observed in women regardless of the <i>APOE</i> allele.
Authors
- Stephanie Webster
- Alexander M. Kulminski (ORCID: https://orcid.org/0000-0002-0205-8228)
- Yury Loika (ORCID: https://orcid.org/0000-0001-6730-7320)
- Elena Loiko
Institutions
- Social Science Research Council (US)
- Duke University (US)
Publication Details
- Journal
- Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring
- Published
- 2024-10-01
- DOI
- https://doi.org/10.1002/dad2.70016
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institute on Aging