Exposure to Nicotine and Withdrawal in Wistar Rats: An Electrophysiological Study

This study demonstrated that nicotine increases high-frequency brain oscillations, which is associated with addiction, whereas withdrawal elevates the delta wave power, suggesting craving. Re-exposure to nicotine following withdrawal restores rapidly the EEG profile of chronic dependence. In addition, nicotine has deleterious impacts on cardiac activity, which are linked to fatal arrhythmias. This implies that stopping smoking is beneficial for the amelioration of the alterations in heart rhythm caused by nicotine addiction. This study elucidates the functional states of the brain and heart during both sporadic and chronic nicotine use, and the electrophysiological explanation for substance dependence and drug relapse after craving episodes.

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Publication Details

Journal
Nicotine & Tobacco Research
Published
2024-10-12
DOI
https://doi.org/10.1093/ntr/ntae240
Citations
1
Primary Topic
Nicotinic Acetylcholine Receptors Study
Type
article
Field-Weighted Citation Impact
0.23
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article

Exposure to Nicotine and Withdrawal in Wistar Rats: An Electrophysiological Study

Fernanda Myllena Sousa Campos, Allan Carlos da Silva Tiago, Moisés Hamoy, Danielma Carvalho de Lima et al.
1 citations
Nicotine & Tobacco Research
Nicotinic Acetylcholine Receptors Study
0.23
article

Exposure to Nicotine and Withdrawal in Wistar Rats: An Electrophysiological Study

Fernanda Myllena Sousa Campos, Allan Carlos da Silva Tiago, Moisés Hamoy, Danielma Carvalho de Lima, Suzane Maia da Fonseca, João Cleiton Martins Rodrigues, Vitoria Corrêa Santos, Dielly Catrina Favacho Lopes, Mariana Kondo Obara, M. V. C. REIS, Esther Padilha da Silveira, Maria Klara Otake Hamoy, Walace Gomes Leal, Josuelem Portela Castro, Rafaella Marques Ribeiro
article en
1 citations

Abstract

This study demonstrated that nicotine increases high-frequency brain oscillations, which is associated with addiction, whereas withdrawal elevates the delta wave power, suggesting craving. Re-exposure to nicotine following withdrawal restores rapidly the EEG profile of chronic dependence. In addition, nicotine has deleterious impacts on cardiac activity, which are linked to fatal arrhythmias. This implies that stopping smoking is beneficial for the amelioration of the alterations in heart rhythm caused by nicotine addiction. This study elucidates the functional states of the brain and heart during both sporadic and chronic nicotine use, and the electrophysiological explanation for substance dependence and drug relapse after craving episodes.

Nicotine & Tobacco ResearchVol. 27(6)
Universidade Federal do Oeste do Pará (BR), Morpho (United States) (US), Instituto Federal de Educação, Ciência e Tecnologia do Pará (BR), Universidade Federal do Pará (BR)
Good health and well-being
Openalex Percentile: Top 42%
Nicotinic Acetylcholine Receptors Study
0.23
DOISourceOpenAlex
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Exposure to Nicotine and Withdrawal in Wistar Rats: An Electrophysiological Study — Fernanda Myllena Sousa Campos, Allan Carlos da Silva Tiago, et al. · Nicotine & Tobacco Research (2024) | TGRS Research Map | TGRS