Leveraging high-throughput analytics and automation to rapidly develop high-concentration mAb formulations: integrated excipient compatibility and viscosity screening
Hence, it is important to optimize the levels of each chosen excipient in the formulation study to balance their benefits against potential incompatibilities. This study serves as a foundation for identifying high-concentration antibody formulations using a high-throughput approach, where minimal materials are required, and optimized formulation design spaces can be quickly identified.
Authors
- Claudia Berdugo
- Lun Xin
- Mourad Mellal
- Jingtao Zhang (ORCID: https://orcid.org/0000-0002-9548-7805)
- Yunsong Li (ORCID: https://orcid.org/0000-0001-7356-2811)
- R. S. Vaughan (ORCID: https://orcid.org/0000-0001-6066-4595)
- Nathan McChesney
- Lan Lan
Institutions
- Catalent (United States) (US)
Publication Details
- Journal
- Antibody Therapeutics
- Published
- 2024-10-01
- DOI
- https://doi.org/10.1093/abt/tbae028
- Citations
- 8
- Primary Topic
- Protein purification and stability
- Type
- article
- Field-Weighted Citation Impact
- 1.87