Leveraging high-throughput analytics and automation to rapidly develop high-concentration mAb formulations: integrated excipient compatibility and viscosity screening

Hence, it is important to optimize the levels of each chosen excipient in the formulation study to balance their benefits against potential incompatibilities. This study serves as a foundation for identifying high-concentration antibody formulations using a high-throughput approach, where minimal materials are required, and optimized formulation design spaces can be quickly identified.

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Publication Details

Journal
Antibody Therapeutics
Published
2024-10-01
DOI
https://doi.org/10.1093/abt/tbae028
Citations
8
Primary Topic
Protein purification and stability
Type
article
Field-Weighted Citation Impact
1.87
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article

Leveraging high-throughput analytics and automation to rapidly develop high-concentration mAb formulations: integrated excipient compatibility and viscosity screening

Claudia Berdugo, Lun Xin, Mourad Mellal, Jingtao Zhang et al.
8 citations
Antibody Therapeutics
Protein purification and stability
1.87
article

Leveraging high-throughput analytics and automation to rapidly develop high-concentration mAb formulations: integrated excipient compatibility and viscosity screening

Claudia Berdugo, Lun Xin, Mourad Mellal, Jingtao Zhang, Yunsong Li, R. S. Vaughan, Nathan McChesney, Lan Lan
article en
8 citations

Abstract

Hence, it is important to optimize the levels of each chosen excipient in the formulation study to balance their benefits against potential incompatibilities. This study serves as a foundation for identifying high-concentration antibody formulations using a high-throughput approach, where minimal materials are required, and optimized formulation design spaces can be quickly identified.

Antibody TherapeuticsVol. 7(4)
Catalent (United States) (US)
Openalex Percentile: Top 14%
Protein purification and stability
1.87
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