Associations between methamphetamine use disorder and <i>SLC18A1</i> , <i>SLC18A2</i> , <i>BDNF</i> , and <i>FAAH</i> gene sequence variants and expression levels
<i>SLC18A1</i> is identified for the first time to play a potential role in methamphetamine use disorder. Lower levels of blood <i>SLC18A2</i> and <i>FAAH</i> mRNA in people with methamphetamine use disorder suggest reduced monoamine reuptake, recycling, or release, and higher anandamide levels in this clinical group, which may be potential therapeutic targets.
Authors
- Zoe Liu (ORCID: https://orcid.org/0000-0002-0269-0119)
- Andrew J. Lawrence (ORCID: https://orcid.org/0000-0001-6836-727X)
- Briana Spolding
- Trang T. T. Truong (ORCID: https://orcid.org/0000-0001-9301-5911)
- Courtney Swinton
- Alexandre A. Guerin (ORCID: https://orcid.org/0000-0003-3833-3620)
- Eric J. Nestler (ORCID: https://orcid.org/0000-0002-7905-2000)
- Yvonne Bonomo (ORCID: https://orcid.org/0000-0003-2583-0687)
- Ken Walder (ORCID: https://orcid.org/0000-0002-6758-4763)
- Susan Lee Rossell (ORCID: https://orcid.org/0000-0002-7415-8252)
- Kiymet Bozaoglu
- Michael Berk (ORCID: https://orcid.org/0000-0002-5554-6946)
- Brian Dean (ORCID: https://orcid.org/0000-0001-7773-4473)
- Jee Hyun Kim (ORCID: https://orcid.org/0000-0002-1299-4300)
- Peter J. Hamilton (ORCID: https://orcid.org/0000-0002-6819-8346)
- Bryan R. Parry
Institutions
- Allen Institute for Brain Science (US)
- Barwon Health (AU)
- Royal Women's Hospital (AU)
- Deakin University (AU)
- The University of Melbourne (AU)
- Virginia Commonwealth University (US)
- Florey Institute of Neuroscience and Mental Health (AU)
- St Vincent's Hospital Melbourne (AU)
- Orygen (AU)
- Murdoch Children's Research Institute (AU)
- Swinburne University of Technology (AU)
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- Dialogues in Clinical Neuroscience
- Published
- 2024-10-12
- DOI
- https://doi.org/10.1080/19585969.2024.2413476
- Citations
- 4
- Primary Topic
- Neurotransmitter Receptor Influence on Behavior
- Type
- article
- Field-Weighted Citation Impact
- 1.07
Funders
- Medical Research Council
- National Health and Medical Research Council