Clinical, molecular, and immunologic mechanisms of CMV retinitis: evolving understanding in HIV and non-HIV immunosuppressed patients
Cytomegalovirus retinitis (CMVR) remains a major cause of vision loss in immunocompromised individuals. CMVR presents differently in HIV-positive and HIV-negative patients, suggesting a possible variation in underlying pathophysiology between the two groups. More research is needed to characterize the potential differences in molecular mechanisms, immunopathology, and genetic markers implicated in the development of CMVR in these populations to develop targeted therapies.
Authors
- Christopher D. Conrady (ORCID: https://orcid.org/0000-0002-8531-0037)
- Thomas A. Albini (ORCID: https://orcid.org/0000-0003-2199-9047)
- Helen Song (ORCID: https://orcid.org/0000-0002-6375-1894)
- Steven Yeh (ORCID: https://orcid.org/0000-0002-5417-7771)
- Jack Begley
- Collin Asheim
Institutions
- University of Miami (US)
- Emory University (US)
- University of Nebraska Medical Center (US)
Publication Details
- Journal
- Expert Review of Ophthalmology
- Published
- 2024-10-12
- DOI
- https://doi.org/10.1080/17469899.2024.2417067
- Citations
- 2
- Primary Topic
- Cytomegalovirus and herpesvirus research
- Type
- article
- Field-Weighted Citation Impact
- 0.77
Funders
- U.S. Department of Health and Human Services
- Edward Mallinckrodt, Jr. Foundation
- Retina Research Foundation
- National Institutes of Health
- National Eye Institute