Decreasing of Trimethylamine N-Oxide by Cecal Microbiota and Choline-Trimethylamine Lyase are Associated with Sishen Pill on Diarrhea with Kidney-Yang Deficiency Syndrome
SSP significantly alleviated the symptoms of diarrhea with kidney-yang deficiency syndrome by modulating the cecal microbiota, downregulating CutC activity, and reducing TMAO and inflammatory factor levels. The cecal microbiota-CutC-TMAO-inflammatory cytokine axis may be a key mechanism underlying the therapeutic effects of SSP.
Authors
- Zhoujin Tan (ORCID: https://orcid.org/0000-0003-3193-073X)
- Maijiao Peng
- Nenqun Xiao (ORCID: https://orcid.org/0000-0002-6036-0046)
- Zhijun Lei (ORCID: https://orcid.org/0009-0007-0684-4860)
- Yi Wu (ORCID: https://orcid.org/0000-0002-8729-2178)
- Mingmin Guo
Institutions
- Hunan University of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Journal of Inflammation Research
- Published
- 2024-10-01
- DOI
- https://doi.org/10.2147/jir.s470254
- Citations
- 18
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 4.21