Extracellular vesicles from human cardiac stromal cells up-regulate cardiomyocyte protective responses to hypoxia
This study demonstrates the potential of cardiac tissues, routinely discarded following surgery, as a valuable source of EVs for myocardial infarction therapy. We also identify miR-1260a as protective of CM hypoxia.
Authors
- Rachel A. Oldershaw (ORCID: https://orcid.org/0000-0001-8478-599X)
- Dora Livkisa
- Max M. Chen (ORCID: https://orcid.org/0000-0002-1063-6710)
- Annette Meeson (ORCID: https://orcid.org/0000-0002-5024-5511)
- Helen Nguyễn (ORCID: https://orcid.org/0000-0001-8015-5296)
- David J. Lundy (ORCID: https://orcid.org/0000-0003-0848-3206)
- Andreas Czosseck (ORCID: https://orcid.org/0009-0008-5746-3598)
- Chuan-Chih Hsu (ORCID: https://orcid.org/0000-0002-3772-1704)
- Gleb Shamrin
Institutions
- University of Liverpool (GB)
- Taipei Medical University Hospital (TW)
- Taipei Medical University (TW)
- Newcastle University (GB)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2024-10-12
- DOI
- https://doi.org/10.1186/s13287-024-03983-y
- Citations
- 6
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 1.40
Funders
- Academia Sinica
- National Science and Technology Council
- Office of Research and Development, Taipei Medical University