Biological Findings and Clinical Outcomes in Patients Treated With R‐<scp>CHOP</scp> Plus High‐Dose Methotrexate as First‐Line Therapy in Large B‐Cell Lymphoma With Testis Involvement

Primary testicular lymphoma (PTL) is a rare occurrence of diffuse large B-cell lymphoma (DLBCL) that accounts for 1%-2% of all cases. Nodal DLBCL with testis involvement (DLBCL-T) and PTL are associated with poor prognosis, with high incidence of central nervous system relapse. Fifteen patients (median age 60 years) with PTL (n = 5) or DLBCL-T (n = 10) received high-dose methotrexate + R-CHOP. Overall, complete response (CR) rate was 73% and overall response rate 86%. With a 3.9-year median follow-up, 100% of patients with PTL had CR and none relapsed. On the contrary, 55% of DLBCL-T patients achieved CR among which only one was still in remission at the end of follow-up. Molecular parallels between PTL and Primary CNS Lymphoma (PCNSL) suggest shared origins, urging further research for tailored treatments and enhanced understanding of these lymphomas' biology.

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Publication Details

Journal
European Journal Of Haematology
Published
2024-10-12
DOI
https://doi.org/10.1111/ejh.14325
Primary Topic
Lymphoma Diagnosis and Treatment
Type
article
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article

Biological Findings and Clinical Outcomes in Patients Treated With R‐CHOP Plus High‐Dose Methotrexate as First‐Line Therapy in Large B‐Cell Lymphoma With Testis Involvement

Lise Willems, Patrick Villarèse, D. Bouscary, Jérémie Zerbit et al.
European Journal Of Haematology
Lymphoma Diagnosis and Treatment
article

Biological Findings and Clinical Outcomes in Patients Treated With R‐CHOP Plus High‐Dose Methotrexate as First‐Line Therapy in Large B‐Cell Lymphoma With Testis Involvement

Lise Willems, Patrick Villarèse, D. Bouscary, Jérémie Zerbit, Aurore Touzart, Raphaël Liévin, Estelle Balducci, Ludovic Lhermitte, M.R. Vignon, Patricia Palmic, Barbara Burroni, Anne‐Ségolène Cottereau, Justine Decroocq, Sophie Kaltenbach, Patricia Franchi, Vahid Asnafi
article en

Abstract

Primary testicular lymphoma (PTL) is a rare occurrence of diffuse large B-cell lymphoma (DLBCL) that accounts for 1%-2% of all cases. Nodal DLBCL with testis involvement (DLBCL-T) and PTL are associated with poor prognosis, with high incidence of central nervous system relapse. Fifteen patients (median age 60 years) with PTL (n = 5) or DLBCL-T (n = 10) received high-dose methotrexate + R-CHOP. Overall, complete response (CR) rate was 73% and overall response rate 86%. With a 3.9-year median follow-up, 100% of patients with PTL had CR and none relapsed. On the contrary, 55% of DLBCL-T patients achieved CR among which only one was still in remission at the end of follow-up. Molecular parallels between PTL and Primary CNS Lymphoma (PCNSL) suggest shared origins, urging further research for tailored treatments and enhanced understanding of these lymphomas' biology.

European Journal Of HaematologyVol. 114(1)
Hôpital Necker-Enfants Malades (FR), Inserm (FR), Université Paris Cité (FR), Hôpital Cochin (FR), Assistance Publique – Hôpitaux de Paris (FR), Institut des Maladies Génétiques Imagine (FR)
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Openalex Percentile: Top 71%
Lymphoma Diagnosis and Treatment
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