Impaired cardiomyocytes accelerate cardiac hypertrophy and fibrosis by delivering exosomes containing Shh/N-Shh/Gli1 in angiotensin II infused mice
Ang II-induced cardiomyocyte injury leads to cardiac hypertrophy and fibrosis through the release of exosomes carrying Shh signaling. The suppression of exosome secretion or the Shh pathway could offer new strategies for treating HF.
Authors
- Qingyun Luo (ORCID: https://orcid.org/0009-0001-5942-4962)
- Huishi Tan
- Zhi‐Wei Lai (ORCID: https://orcid.org/0000-0001-7314-1814)
- Lishan Tan (ORCID: https://orcid.org/0000-0002-6492-5067)
- Zibo Xiong (ORCID: https://orcid.org/0000-0002-0574-3802)
- Sanmu Li
- Guang Yang (ORCID: https://orcid.org/0000-0001-5271-7079)
- Cong Wang (ORCID: https://orcid.org/0000-0002-2269-4766)
- Hua Zhang
- Zuying Xiong
Institutions
- Hong Kong University of Science and Technology (HK)
- Guangzhou First People's Hospital (CN)
- Peking University Shenzhen Hospital (CN)
- University of Hong Kong - Shenzhen Hospital (CN)
- University of Hong Kong (HK)
- South China University of Technology (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Heliyon
- Published
- 2024-10-01
- DOI
- https://doi.org/10.1016/j.heliyon.2024.e39332
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Science, Technology and Innovation Commission of Shenzhen Municipality
- Sanming Project of Medicine in Shenzhen
- Shenzhen Science and Technology Innovation Program