Challenges and opportunities of next generation therapeutics: A compound management perspective

In recent years, pharmaceutical research has increased its interest in novel drug modalities beyond small molecules to overcome therapeutic limitations and find more effective cures. Compound Management teams globally are adapting their processes and equipment to handle such "new modalities" with the same quality and speed as small molecule research. Here, we share our approach in supporting next-generation therapeutics by introducing solutions for multi-solvent workflows in Compound Management at AstraZeneca. From sample submission to assay-ready plate generation, we describe the challenges faced and process improvements introduced so far. Collaborating with our business partners, we are pioneering new best practices and laying solid foundations for future research to bring new efficacious drugs into the clinics.