Differential transcriptomic host responses in the early phase of viral and bacterial infections in human lung tissue explants ex vivo
Human lung tissue mounted substantially different transcriptomic responses to infection by IAV than by BCG and P. aeruginosa, whereas responses to these two divergent bacterial pathogens were surprisingly similar. This HLTE model should prove useful for RNA-directed pathogenesis research and tissue biomarker discovery during the early phase of infections, both at the tissue and single-cell level.
Authors
- Laurien Czichon (ORCID: https://orcid.org/0000-0001-7772-7468)
- Peter Braubach (ORCID: https://orcid.org/0000-0003-3673-7779)
- Michael Steinert (ORCID: https://orcid.org/0000-0001-9197-6305)
- Stephan Pleschka (ORCID: https://orcid.org/0000-0002-7372-7089)
- Leonardo de Araujo
- Fakhar H. Waqas
- Frank Peßler (ORCID: https://orcid.org/0000-0002-3434-2311)
- Azeem Iqbal (ORCID: https://orcid.org/0000-0003-2329-1675)
- Mohamed Samir (ORCID: https://orcid.org/0000-0002-1166-0480)
- Robert Geffers
- Aaqib Sohail (ORCID: https://orcid.org/0000-0002-5917-7316)
Institutions
- Zagazig University (EG)
- Justus-Liebig-Universität Gießen (DE)
- Medizinische Hochschule Hannover (DE)
- German Center for Infection Research (DE)
- Helmholtz Centre for Infection Research (DE)
- Research Center Borstel - Leibniz Lung Center (DE)
- Centre for Individualised Infection Medicine (DE)
- Center for Experimental and Clinical Infection Research (DE)
- Technische Universität Braunschweig (DE)
Publication Details
- Journal
- Respiratory Research
- Published
- 2024-10-12
- DOI
- https://doi.org/10.1186/s12931-024-02988-8
- Citations
- 9
- Primary Topic
- Cancer-related molecular mechanisms research
- Type
- article
- Field-Weighted Citation Impact
- 2.57
Funders
- National Research Centre
- Justus Liebig Universität Gießen
- European Federation of Pharmaceutical Industries and Associations
- European Commission
- Helmholtz-Gemeinschaft
- Innovative Medicines Initiative