Biological mechanisms of resilience to tau pathology in Alzheimer’s disease
Biomarkers of co-existing pathological processes, in particular vascular pathology and axonal degeneration, interact with levels of tau pathology on its association with the downstream effects of AD pathology (i.e. brain atrophy and cognitive decline). This indicates that vascular pathology and axonal degeneration could impact brain and cognitive resilience.
Authors
- Diana I. Bocancea (ORCID: https://orcid.org/0000-0001-8303-8933)
- Sebastian Palmqvist (ORCID: https://orcid.org/0000-0002-9267-1930)
- Rik Ossenkoppele (ORCID: https://orcid.org/0000-0003-1584-7477)
- Erik Stomrud (ORCID: https://orcid.org/0000-0002-0841-5580)
- Niklas Mattsson (ORCID: https://orcid.org/0000-0002-8885-7724)
- Oskar Hansson (ORCID: https://orcid.org/0000-0001-8467-7286)
- Anita van Loenhoud
- Frederik Barkhof (ORCID: https://orcid.org/0000-0003-3543-3706)
- Anna L. Svenningsson
Institutions
- Lund University (SE)
- Amsterdam Neuroscience (NL)
- Skåne University Hospital (SE)
- Amsterdam University Medical Centers (NL)
- University College London (GB)
- Vrije Universiteit Amsterdam (NL)
- Amsterdam UMC Location Vrije Universiteit Amsterdam (NL)
Publication Details
- Journal
- Alzheimer s Research & Therapy
- Published
- 2024-10-12
- DOI
- https://doi.org/10.1186/s13195-024-01591-9
- Citations
- 7
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 2.29
Funders
- Alzheimer's Association
- National Council for Eurasian and East European Research
- GHR Foundation
- European Commission
- Lunds Universitet
- Hjärnfonden
- Knut och Alice Wallenbergs Stiftelse
- Vetenskapsrådet
- Parkinsonfonden
- European Research Council