PHACTR1 and APOC1 genetic variants are associated with multi-vessel coronary artery disease
Following replication of the associations in the large UK Biobank dataset, it was found that patients carrying the rs9349379*G variant in the PHACTR1 gene are at risk of developing severe or multivessel disease. Conversely, the rs445925*T variant in APOC1/APOE is associated with reduced susceptibility to severe CAD and multivessel disease, highlighting the significance of this genetic variant in these specific CAD presentations. This study contributes to a better understanding of CAD heterogeneity, paving the way for tailored management strategies based on genetic profiles.
Authors
- Antoine Abchee
- Taly Issa
- Stéphanie Chacar (ORCID: https://orcid.org/0000-0003-4073-4749)
- Pierre Zalloua (ORCID: https://orcid.org/0000-0002-8494-5081)
- Cynthia Al Hageh (ORCID: https://orcid.org/0000-0001-8386-4063)
- Andreas Henschel (ORCID: https://orcid.org/0000-0003-1386-5372)
- Moni Nader (ORCID: https://orcid.org/0000-0003-2138-5213)
- Mireille Hantouche (ORCID: https://orcid.org/0000-0002-2820-6321)
- Siobhán O’Sullivan
- Nantia Iakovidou
Institutions
- Harvard University (US)
- University of Balamand (LB)
- University of Nicosia (CY)
- Khalifa University of Science and Technology (AE)
- Aristotle University of Thessaloniki (GR)
Publication Details
- Journal
- Lipids in Health and Disease
- Published
- 2024-10-12
- DOI
- https://doi.org/10.1186/s12944-024-02327-2
- Citations
- 3
- Primary Topic
- Acute Myocardial Infarction Research
- Type
- article
- Field-Weighted Citation Impact
- 1.21
Funders
- Khalifa University of Science, Technology and Research