Spatial multiomics atlas reveals smooth muscle phenotypic transformation and metabolic reprogramming in diabetic macroangiopathy
This study constructs the spatial gene-metabolism map of the whole anterior tibial artery for the first time and reveals the characteristics of vascular calcification, the phenotypic transformation trend of SMCs, and the transcriptional driving network of SMCs phenotypic transformation of diabetic macrovascular disease. In the perspective of combining the transcriptome and metabolome, the study demonstrates the activated metabolic pathways in diabetic blood vessels and the key genes involved in diabetic metabolic reprogramming.
Authors
- Yun Gao (ORCID: https://orcid.org/0000-0002-9958-9374)
- Yongjiang Qian
- Shizheng Xiong (ORCID: https://orcid.org/0000-0003-4810-205X)
- Zhongqun Wang
- Guo Li (ORCID: https://orcid.org/0000-0003-3911-6978)
- Haipeng Yao (ORCID: https://orcid.org/0000-0001-7160-7107)
- Guoquan Feng (ORCID: https://orcid.org/0000-0002-7195-7948)
- Xiaoguang Wang (ORCID: https://orcid.org/0000-0002-4079-9596)
- Lihua Li (ORCID: https://orcid.org/0000-0002-2089-8140)
- WEI KANG YUAN (ORCID: https://orcid.org/0000-0003-4235-2533)
- Honghua Cai
- Zhen Sun (ORCID: https://orcid.org/0000-0003-3368-1976)
- Lili Zhang (ORCID: https://orcid.org/0009-0005-7341-1438)
Institutions
- Jiangsu University (CN)
- Nanjing University of Posts and Telecommunications (CN)
- Affiliated Hospital of Jiangsu University (CN)
Publication Details
- Journal
- Cardiovascular Diabetology
- Published
- 2024-10-12
- DOI
- https://doi.org/10.1186/s12933-024-02458-x
- Citations
- 21
- Primary Topic
- Adipose Tissue and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 6.86
Funders
- National Natural Science Foundation of China
- Jiangsu Provincial Key Research and Development Program