Marine collagen extraction methods for solving regenerative medicine problems

Modern regenerative medicine widely uses collagen-based products and products, the most popular being collagen of animal origin. The use of such collagen is associated with a number of difficulties, incl. with the occurrence of active immune reactions, as well as with religious and cultural restrictions that do not allow the use of drugs made from animal tissue. Marine collagen, which does not have these disadvantages, can be a successful alternative to collagen from animal sources. The current geopolitical situation forces us to look for domestic sources of collagen. The article provides an overview of methods for extracting collagen from jellyfish biomass. Promising species of jellyfish suitable for implementing these methods are considered. It has been shown that on the territory of the Russian Federation, the most productive and promising jellyfish of the family Rhizostomatidae of the order of Rhizostoma pulmo , living in the Black Sea. The jellyfish Aurelia aurita of the order of disc jellyfish (Semaeostomeae), despite its prevalence (lives in almost all seas of Russia), has a low content of dry substances in its biomass and is difficult to catch due to the small weight of individuals. Of the extraction methods considered in relation to jellyfish biomass, mixed enzymatic and acidic extraction using organic acids should be considered the most suitable. The enzymatic method using pepsin is applicable to the biomass of Aurelia aurita jellyfish, because The jellyfish biomass is completely dissolved in the first stage of enzymatic extraction.