The prognostic and immune significance of Rab11A in pan‐cancer and its function and mechanism underlying estrogen receptor targeting in breast cancer
Rab11A expression in pan-cancer is associated with poor prognosis and immune profile. In particular, in BRCA, Rab11A expression regulates cell proliferation by targeting ERα and ERβ. High Rab11A expression is tightly associated with immune characteristics, tumor microenvironment, and genetic mutations. These results provide a reference for exploring the role of Rab11A in pan-cancer and provide a new perspective for revealing potential therapeutic targets in BRCA.
Authors
- Jianye Deng
- Wenjin Zhang (ORCID: https://orcid.org/0000-0002-3541-7282)
- Jun Hao (ORCID: https://orcid.org/0000-0002-1213-0449)
- Ruihuan Fu
- Yuhui Bu (ORCID: https://orcid.org/0000-0002-6441-9690)
- Xiaolu Yang (ORCID: https://orcid.org/0000-0002-1716-5640)
- Yinfeng Liu (ORCID: https://orcid.org/0000-0002-1427-4462)
- Mengyu Wei
- Jianchao He (ORCID: https://orcid.org/0000-0003-3387-8437)
- Lin Zhu
- Geng Zhang (ORCID: https://orcid.org/0000-0001-9038-4316)
- Shuo Zhang (ORCID: https://orcid.org/0000-0002-4952-576X)
- Li Ma (ORCID: https://orcid.org/0009-0006-5425-4470)
- Yilun Li (ORCID: https://orcid.org/0000-0001-7896-3374)
- Yan Ding (ORCID: https://orcid.org/0000-0001-6391-1977)
- Baifang Ding
- Xiaohuan Bao
Institutions
- Hebei Medical University (CN)
- Third Hospital of Hebei Medical University (CN)
- Fourth Hospital of Hebei Medical University (CN)
- Jiangjin Central Hospital (CN)
Publication Details
- Journal
- Asia-Pacific Journal of Clinical Oncology
- Published
- 2024-10-12
- DOI
- https://doi.org/10.1111/ajco.14130
- Primary Topic
- Cellular transport and secretion
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China