Targeted delivery of napabucasin with radiotherapy improves outcomes in diffuse midline glioma
As nearly all DMG patients will receive RT as part of their treatment course, our validation of the efficacy of radiosensitizing therapy using CED to prolong survival in DMG opens the door for exciting novel studies of alternative radiosensitization strategies in this devastating disease while overcoming limitations of the BBB.
Authors
- Neil A. Feldstein (ORCID: https://orcid.org/0009-0001-2352-1031)
- J Carlos Angel (ORCID: https://orcid.org/0000-0001-5240-0696)
- Ester Calvo Fernández (ORCID: https://orcid.org/0000-0001-6307-8452)
- Shoufu Duan (ORCID: https://orcid.org/0000-0003-0416-374X)
- Simon K. Cheng (ORCID: https://orcid.org/0000-0001-5276-6647)
- Danae Kokossis (ORCID: https://orcid.org/0000-0001-6285-3728)
- Fereshteh Zandkarimi (ORCID: https://orcid.org/0000-0001-8618-3669)
- Xander Berg (ORCID: https://orcid.org/0009-0003-1365-6877)
- Robyn D. Gartrell (ORCID: https://orcid.org/0000-0003-3287-4223)
- Cheng–Chia Wu (ORCID: https://orcid.org/0000-0002-5908-0143)
- Peter Canoll
- Stergios Zacharoulis
- Jovana Pavisic (ORCID: https://orcid.org/0000-0002-6968-600X)
- Andrea Califano (ORCID: https://orcid.org/0000-0003-4742-3679)
- Nina Yoh (ORCID: https://orcid.org/0000-0002-3058-9122)
- Matthew Gallitto (ORCID: https://orcid.org/0000-0002-5210-742X)
- Jeffrey N. Bruce (ORCID: https://orcid.org/0000-0002-6844-0286)
- Hong-Jian Wei (ORCID: https://orcid.org/0000-0002-5962-7831)
- Robert J. Wechsler‐Reya (ORCID: https://orcid.org/0000-0002-7463-8352)
- Geoffrey Sedor (ORCID: https://orcid.org/0000-0001-5286-3148)
- Connor J. Kinslow (ORCID: https://orcid.org/0000-0001-8888-6077)
- Iok In Christine Chio (ORCID: https://orcid.org/0000-0002-3635-2679)
- Lorenzo Tomassoni (ORCID: https://orcid.org/0000-0002-7720-9166)
- James H. Garvin (ORCID: https://orcid.org/0000-0003-4709-1088)
- Zhiguo Zhang (ORCID: https://orcid.org/0000-0002-9451-2685)
- Xu Zhang (ORCID: https://orcid.org/0000-0002-9817-4492)
- Yifang Wang (ORCID: https://orcid.org/0000-0003-1980-1126)
- Genesis De Los Santos
- Erin J. White
Institutions
- Broad Institute (US)
- Memorial Sloan Kettering Cancer Center (US)
- Children's National (US)
- Harvard University (US)
- Johns Hopkins University (US)
- Chinese Academy of Sciences (CN)
- Columbia University Irving Medical Center (US)
- Johns Hopkins Medicine (US)
- Massachusetts General Hospital (US)
- Center for Cancer and Blood Disorders (US)
- Chan Zuckerberg Initiative (United States) (US)
- Czech Academy of Sciences, Institute of Microbiology (CZ)
- Biomedical Research Institute (US)
- Cancer Genetics (United States) (US)
- DarwinHealth (United States) (US)
- Center for Cancer Research (US)
- Neurological Surgery (US)
- Chan Zuckerberg Biohub New York
- Carilion Clinic (US)
- Columbia University (US)
- Virginia Tech (US)
Publication Details
- Journal
- Neuro-Oncology
- Published
- 2024-10-12
- DOI
- https://doi.org/10.1093/neuonc/noae215
- Citations
- 5
- Primary Topic
- Glioma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 2.19
Funders
- Musella Foundation For Brain Tumor Research and Information
- Rally Foundation
- Massachusetts General Hospital
- Radiological Society of North America
- American Society of Clinical Oncology
- Focused Ultrasound Foundation
- Memorial Sloan-Kettering Cancer Center
- Virginia Polytechnic Institute and State University
- Johns Hopkins University
- “la Caixa” Foundation
- Broad Institute
- Strong
- Swim Across America
- Children's National Hospital
- Chinese Academy of Sciences
- State Key Laboratory of Mycology
- National Institutes of Health
- Irving Medical Center, Columbia University
- Vagelos College of Physicians and Surgeons, Columbia University
- Institute of Microbiology, Chinese Academy of Sciences
- National Cancer Institute