Resident memory B cells are enriched in chronic rhinosinusitis with nasal polyps
Our findings in this study reveal that BRM cells can be detected in normal sinonasal mucosa, although they are significantly enriched in nasal polyps derived from patients with CRSwNP. These findings can contribute to gaining a more comprehensive understanding of the immune reactions associated with CRSwNP and facilitate the identification of potential therapeutic targets, such as anti-B-cell therapy.
Authors
- Mamoru Yoshikawa (ORCID: https://orcid.org/0000-0002-5908-1752)
- Nobuyoshi Otori (ORCID: https://orcid.org/0000-0001-5917-5452)
- Tomomitsu Hirota
- Natsuki Inoue (ORCID: https://orcid.org/0000-0002-6794-3885)
- Tsuguhisa Nakayama (ORCID: https://orcid.org/0000-0001-8761-9292)
- Yohei Sato (ORCID: https://orcid.org/0000-0002-8042-0069)
- Daiki Nakashima (ORCID: https://orcid.org/0000-0002-8459-3733)
- Erika Osada
- Yasuhiro Tsunemi
- Shinichi Haruna
Institutions
- Jikei University School of Medicine (JP)
- Toho University (JP)
- Toho University Ohashi Medical Center (JP)
- Dokkyo Medical University (JP)
Publication Details
- Journal
- Journal of Allergy and Clinical Immunology Global
- Published
- 2024-10-12
- DOI
- https://doi.org/10.1016/j.jacig.2024.100349
- Citations
- 1
- Primary Topic
- Sinusitis and nasal conditions
- Type
- article
- Field-Weighted Citation Impact
- 0.58
Funders
- Jikei University School of Medicine