Plasma metabolites, systolic blood pressure, lifestyle, and stroke risk: A prospective cohort study
Various metabolites and MRS were significantly associated with the risk of stroke, IS, ICH, and SAH. Individuals with a high MRS may face an elevated stroke risk among populations with high SBP or unhealthy lifestyle, even those with normal SBP or healthy lifestyle. MRS provided modest improvement to the stroke risk prediction model. The lifestyle-related metabolic signature could reduce 20% stroke risk.
Authors
- Jinyao Huang
- Dongsheng Hu (ORCID: https://orcid.org/0000-0002-9998-8041)
- Fulan Hu (ORCID: https://orcid.org/0000-0002-2386-1503)
- Canjia Zhang
- Ziyuan Yu (ORCID: https://orcid.org/0000-0002-7029-4468)
- Yongqiang Liang
- Xi Chen (ORCID: https://orcid.org/0000-0002-3160-614X)
- Mingxiao Li (ORCID: https://orcid.org/0000-0002-2715-4806)
- Miaomiao Yang (ORCID: https://orcid.org/0000-0002-3438-7958)
- Jiaqi Lin (ORCID: https://orcid.org/0000-0003-1383-6723)
- Ying Lin
- Yuanhai Yang
- Ming Zhang (ORCID: https://orcid.org/0000-0002-1800-9041)
Institutions
- Fujian Medical University (CN)
- Shenzhen University (CN)
- Shenzhen University Health Science Center (CN)
Publication Details
- Journal
- International Journal of Stroke
- Published
- 2024-10-12
- DOI
- https://doi.org/10.1177/17474930241293408
- Citations
- 1
- Primary Topic
- Metabolomics and Mass Spectrometry Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.23