Interplay between the SAFE and the sphingolipid pathway for cardioprotection
Our data strongly suggest SK1 as a key component to activate STAT-3 downstream of TNF-α in the SAFE pathway, paving the way for the development of novel cardioprotective strategies that may target SK1 to modulate the SAFE pathway and increase cell survival following IRI.
Authors
- Damian Hacking
- Derek J. Hausenloy (ORCID: https://orcid.org/0000-0003-0729-4956)
- Martin Cour (ORCID: https://orcid.org/0000-0003-4909-9761)
- Frederic Nduhirabandi
- Sarah Pedretti (ORCID: https://orcid.org/0000-0003-4005-8453)
- Miguel A. Frias (ORCID: https://orcid.org/0000-0001-6884-4793)
- Sandrine Lecour (ORCID: https://orcid.org/0000-0003-1942-8974)
Institutions
- University of Cape Town (ZA)
- University Hospital of Geneva (CH)
- South African Heart Association (ZA)
- University College London (GB)
Publication Details
- Journal
- Life Sciences
- Published
- 2024-10-12
- DOI
- https://doi.org/10.1016/j.lfs.2024.123145
- Citations
- 1
- Primary Topic
- Sphingolipid Metabolism and Signaling
- Type
- article
- Field-Weighted Citation Impact
- 0.23