PD-L1 blockade immunotherapy rewires cancer-induced emergency myelopoiesis
Our findings shed light on unrecognized mechanisms of action of ICB immunotherapy in cancer, which involves targeting of BM-driven HSPCs and reprogramming of cancer-induced emergency myelopoiesis.
Authors
- Iosif Papafragkos
- Aikaterini Hatzioannou
- Eirini Trompouki (ORCID: https://orcid.org/0000-0002-7242-8810)
- Eleni Gavriilaki (ORCID: https://orcid.org/0000-0002-8883-8208)
- Athina Boumpas
- Louis Boon (ORCID: https://orcid.org/0000-0002-0937-9171)
- Panayotis Verginis (ORCID: https://orcid.org/0000-0002-1282-5435)
- Antonia Vlachou
- Manousos Makridakis (ORCID: https://orcid.org/0000-0002-0063-3559)
- Athanasios Tasis (ORCID: https://orcid.org/0000-0002-8411-961X)
- Veronica Bergo
- Pavlos Bousounis (ORCID: https://orcid.org/0000-0001-9294-0857)
- Antonis Papaioannou (ORCID: https://orcid.org/0000-0001-5658-6096)
- Ioannis Mitroulis (ORCID: https://orcid.org/0000-0002-9991-2362)
- Maria Grigoriou (ORCID: https://orcid.org/0000-0001-5383-4138)
- Michael Iskas
Institutions
- Centre National de la Recherche Scientifique (FR)
- University of Crete (GR)
- Democritus University of Thrace (GR)
- Inserm (FR)
- University of Freiburg (DE)
- Academy of Athens (GR)
- Biomedical Research Foundation of the Academy of Athens (GR)
- FORTH Institute of Molecular Biology and Biotechnology (GR)
- Institut de Recherche sur le Cancer et le Vieillissement de Nice (FR)
- G. Papanikolaou General Hospital (GR)
- University Hospital of Alexandroupolis (GR)
- Max Planck Institute of Immunobiology and Epigenetics (DE)
- Technische Universität Dresden (DE)
- Foundation for Research and Technology Hellas (GR)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2024-10-11
- DOI
- https://doi.org/10.3389/fimmu.2024.1386838
- Citations
- 2
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 0.57
Funders
- Deutsche Forschungsgemeinschaft
- General Secretariat for Research and Technology