Protein kinase D1 in myeloid lineage cells contributes to the accumulation of CXCR3+CCR6+ nonconventional Th1 cells in the lungs and potentiates hypersensitivity pneumonitis caused by S. rectivirgula
Our results demonstrate that PKD1 in myeloid-lineage cells plays an essential role in the development and progress of HP caused by repeated exposure to <i>S. rectivirgula</i> by contributing Th1/Th17 polarizing proinflammatory responses, alveolitis, and accumulation of pathogenic nonconventional Th1 cells in the lungs.
Authors
- Priyanka Halder
- Elizabeth Fitzpatrick (ORCID: https://orcid.org/0000-0003-4149-3764)
- Tae Won Yoon (ORCID: https://orcid.org/0000-0003-4581-0376)
- Sang‐Min Lee (ORCID: https://orcid.org/0000-0002-1388-9318)
- John D. Snyder (ORCID: https://orcid.org/0000-0003-3545-9420)
- Ae-Kyung Yi
Institutions
- University of Tennessee Health Science Center (US)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2024-10-11
- DOI
- https://doi.org/10.3389/fimmu.2024.1403155
- Citations
- 2
- Primary Topic
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Type
- article
- Field-Weighted Citation Impact
- 0.84
Funders
- National Institutes of Health
- Health Science Center, University of Tennessee