Toll-like receptor 7 protects against intestinal inflammation and restricts the development of colonic tissue-resident memory CD8+ T cells
In conclusion, the convergence of ATG16L1 and TLR7 signaling pathways plays an important role in the immune response to intestinal viruses. Our data suggest that activation of the TLR7 signaling pathway could be an attractive therapeutic target for CD patients with <i>ATG16L1</i> risk variants.
Authors
- Michelle Wong (ORCID: https://orcid.org/0000-0002-6404-8383)
- Jordan Nunnelee (ORCID: https://orcid.org/0000-0002-2924-9825)
- Lisa Thomas
- Dalton T. Stamps
- Jasmine T. Stamps
- Hussein Hamade (ORCID: https://orcid.org/0000-0002-4063-8821)
- Masato Tsuda (ORCID: https://orcid.org/0000-0002-1982-2456)
- Brenda Salumbides (ORCID: https://orcid.org/0000-0003-1423-7845)
- Deepti Dhall
- Caroline Jin
- Kathrin S. Michelsen (ORCID: https://orcid.org/0000-0002-4974-6992)
- Naoki Oshima (ORCID: https://orcid.org/0000-0002-0861-9970)
- Stephan Targan
Institutions
- Cedars-Sinai Medical Center (US)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2024-10-11
- DOI
- https://doi.org/10.3389/fimmu.2024.1465175
- Citations
- 6
- Primary Topic
- Immune Cell Function and Interaction
- Type
- article
- Field-Weighted Citation Impact
- 1.44
Funders
- Crohn's and Colitis Foundation of America
- Crohn's and Colitis Foundation
- National Institutes of Health
- National Institute of Diabetes and Digestive and Kidney Diseases