SIRT1 modulates microglia phenotypes via inhibiting drp1 phosphorylation reduces neuroinflammation in heatstroke
Our findings provided evidence that SIRT1 played a crucial role in inhibiting heat stress-induced microglial activation. By suppressing the phosphorylation of mitochondrial fission protein Drp1, SIRT1 contributed to the reduction of neuroinflammation and severity of heatstroke-induced brain injury.
Authors
- Panshi Jin
- Jie Zhu (ORCID: https://orcid.org/0000-0001-5304-7708)
- Guangli Ren
- Zhen Tang (ORCID: https://orcid.org/0000-0001-6068-510X)
- Zhifeng Liu (ORCID: https://orcid.org/0000-0001-5124-9824)
- Zixin Wang (ORCID: https://orcid.org/0000-0002-1158-2304)
- Dingshun Zhang
- Tingting Zhou (ORCID: https://orcid.org/0000-0003-4784-1790)
Institutions
- Guangzhou University of Chinese Medicine (CN)
- Army Medical University (CN)
- Third Affiliated Hospital of Southern Medical University (CN)
- General Hospital of Guangzhou Military Command (CN)
- Zhujiang Hospital (CN)
- Southern Medical University (CN)
Publication Details
- Journal
- Brain Research Bulletin
- Published
- 2024-10-11
- DOI
- https://doi.org/10.1016/j.brainresbull.2024.111101
- Citations
- 4
- Primary Topic
- Sirtuins and Resveratrol in Medicine
- Type
- article
- Field-Weighted Citation Impact
- 1.38