Design, Synthesis and Characterization of 5-(2-Bromo-5-Fluorophenyl)-3-(1h-Pyrrol-2-Yl)-4,5-Dihydro-1h-Pyrazole as Antifungal Agent

This study successfully synthesized a novel compound (5-(2-bromo-5-fluorophenyl)-3-(1H-pyrrol-2-yl)-4,5-dihydro-1H-pyrazole (6), from an α, β-unsaturated carbonyl compound (5). The compound was characterized using various spectroscopic techniques, including 1???? NMR, 13???? NMR, and mass spectrometry. Its antifungal potential was evaluated against three fungal strains including Candida tropicalis, Candida parapsilosis, and Candida albicans. The results indicated that compound (6) exhibited moderate antifungal activity. Furthermore, molecular descriptors and ADMET profiling were employed in an in-silico simulation to assess the compound's drug-likeness. This study thus presents a valuable strategy for developing more effective antifungal agents.