Natural Phycocyanin/Paclitaxel Micelle Delivery of Therapeutic P53 to Activate Apoptosis for HER2 or ER Positive Breast Cancer Therapy
The <i>P53</i> gene is commonly mutated in breast cancer, protein based the gene as anticancer drugs could provide efficient and stable advantages by restoring the function of the wild-type P53 protein. In this study, we describe the creation and utilization of a micelle composed by natural phycocyanin and paclitaxel and grafting anti-HER2 (PPH), which effectively packages and transports recombinant P53 protein with anti-ER (PE), resulting in a new entity designated as PE@PPH, to address localization obstacles and modify cellular tropism to the cell membrane or nucleus. The results indicate that PE@PPH has strong antitumor properties, even at low doses of PTX both <i>in vitro</i> and <i>in vivo</i>. These findings suggest that PE@PPH could be an enhancing micelle for delivering therapeutic proteins and promoting protein functional recovery, particularly in addressing the challenges posed by tumor heterogeneity in breast cancer.
Authors
- Runcai Yang (ORCID: https://orcid.org/0000-0001-9567-4777)
- Yuxuan Jiao
- Yan‐Qing Guan (ORCID: https://orcid.org/0000-0002-5560-3998)
- Rong You (ORCID: https://orcid.org/0000-0003-1866-9856)
- Yide Mei (ORCID: https://orcid.org/0000-0002-8670-7394)
- Lingkun Zhang (ORCID: https://orcid.org/0000-0001-8717-4334)
- Yunzhi Tang
- He Ni (ORCID: https://orcid.org/0000-0002-3062-8072)
- Liang Yin (ORCID: https://orcid.org/0000-0003-4745-9196)
- Yuan Li (ORCID: https://orcid.org/0000-0001-5081-6102)
- Jian Ge (ORCID: https://orcid.org/0000-0001-5165-3368)
- Limin Zhai
Institutions
- Sun Yat-sen University (CN)
- South China Normal University (CN)
- Westlake University (CN)
- Institute for Advanced Study (DE)
- Laser Research Institute (CN)
- Zhongshan Ophthalmic Center, Sun Yat-sen University
Publication Details
- Journal
- ACS Biomaterials Science & Engineering
- Published
- 2024-10-11
- DOI
- https://doi.org/10.1021/acsbiomaterials.4c00756
- Citations
- 1
- Primary Topic
- Algal biology and biofuel production
- Type
- article
- Field-Weighted Citation Impact
- 0.10
Funders
- Scientific and Technological Planning Project of Guangzhou City
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation
- State Key Laboratory of Ophthalmology
- Science and Technology Planning Project of Guangdong Province